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Senior Scientist I/II, Protein X-ray Crystallographer

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Job Details
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North Chicago, IL 60064
Job Description

Senior Scientist I/II, Protein X-ray Crystallographer

USA, Illinois, Lake County

Research & Development

Requisition #1907372

Our Protein Crystallography Group located in Lake County, Illinois is seeking a scientist with extensive hands ­on experience in modern X­ray Crystallography techniques and computational methods of molecular structure analysis to join our Structure­Based Drug Discovery team! As a member of our multidisciplinary team, you will utilize fragment­based strategies to identify ligands and provide insight to advance drug discovery targets through structure­based design. Additionally, you will contribute to drug discovery projects across the portfolio of AbbVie interests that also include therapeutic antibodies and novel biologics.

Key Responsibilities:

+ Determine X­ray crystal structures of protein­ligand complexes in high throughput modes and identify strategies for improved molecular designs

+ Support the crystallization and protein construct design efforts for useful sample preparations

+ Utilize Cheminformatics tools and manipulate scripts for use across mixed computing platforms

+ Collaborate with members of Fragment­based Drug Discovery team to advance hit to lead projects

+ Work with biologists, molecular modelers, and medicinal chemists to validate targets of interest

+ Maintain accurate and timely records of experimental results

+ Communicate results and interpretative analysis to project teams and present at internal meetings

+ Publish in peer ­reviewed journals as appropriate and present at external scientific meetings

+ Evaluate the scientific literature critically and embrace novel technologies which will facilitate structure­based drug discovery at AbbVie

Position will be hired based on level of experience.

+ Bachelors, Masters or PhD in Chemistry, Biochemistry, Biophysics, or a related field with typically 10-12+ (BS) 8-10+ (MS) or 0-4+ (PhD) or more years of relevant academic or industry experience

+ Proven ability in protein crystal structure analysis with X­ray or Electron Diffraction data

+ Familiarity with structure based drug design strategies and fragment based approaches; detail oriented and meticulous regarding documentation and data management

+ Work both independently and as part of a highly collaborative, interdisciplinary team

+ Effective written and verbal communication skills

+ Ability to work on multiple projects in parallel and rapidly adjust to changing priorities

Preferred Qualifications:

+ Experience in complementary techniques of macromolecular SAXS analysis or CryoEM

Key Leadership Competencies:

+ Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance.

+ Learns fast, grasps the “essence” and can change course quickly where indicated.

+ Raises the bar and is never satisfied with the status quo.

+ Creates a learning environment, open to suggestions and experimentation for improvement.

+ Embraces the ideas of others, nurtures innovation and manages innovation to reality.

Additional Information

+ Significant Work Activities and Conditions: Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)

+ Travel: Yes, 5 % of the Time

+ Job Type: Experienced

+ Schedule: Full-time

+ Job Level Code: M

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