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Senior Principal Research Scientist I Toxicology

at AbbVie in North Chicago, Illinois, United States

Job Description

Company Description

AbbVie’s mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

Job Description

The primary role is to assess the safety of experimental compounds in animals as well as through use of in vitro systems. Data generated serves to enable project teams to de-risk and advance candidate compounds through early stages of development. The pathologist also acts as subject-matter expert and scientific resource for other departments, working cross-functionally as a key contributing member to project teams. Additional tasks include design and conduct of study protocols, evaluation of clinical and anatomic pathology data, presentation of data, and preparation of reports. The successful candidate will be scientifically curious, a team player, and strive to deliver innovative solutions to improve patients’ lives.

Responsibilities

+ Serves as early safety representative on drug discovery teams. Predict possible toxicities, develop safety screens to detect, and mitigation strategies to avoid potential toxicities and prioritize the safest compounds for progression to development.

+ Executes scientific strategy in alignment with cross-functional, cross-disciplinary goals and key scientific goals.

+ Establishes scientific standards for excellence by collaborating with multi-disciplinary functional leaders and experts to integrate standards into strategies and tactics.

+ Proactively advises and shares knowledge and expert opinions with senior management.

+ Delivers results that meet or exceed expectations of major project plans across function through sound design, early risk assessments, and implementation of fallback strategies.

+ Anticipates challenges and continually set approaches to utilize new technology.

+ Keeps stakeholders informed by presenting scientific concepts and results for functional and non-scientific leaders and other partners.

+ Designs, directs, conducts, and evaluates studies to determine the potential toxicity of experimental compounds in different species of animals. This involves interpretation of data in the field of pathology (necropsy, histopathology, clinical pathology, electron microscopy, etc.)

+ Integrates the anatomic pathology data, clinical pathology data, and other study findings to generate a pathology report as a component of the toxicology report.

+ Provides input to study protocols, supervise necropsies, perform histological examinations in rodent and non-rodent studies, author pathology reports, conduct peer reviews, and review regulatory documents.

+ Partners with regulatory toxicologists, pathologists, pharmacokineticists, pharmacologists, and other functions to develop optimal strategies to address specific toxicology issues as well as select and advance development compounds.

+ Provides professional consultation to scientific staff of other departments and provides professional supervision to assigned technical areas. Provide scientific and technical expertise to project teams.

+ Maintains external reputation as multidiscipline expert and leads industry as an invited speaker at external meetings, as well as authoring and reviewing high-impact articles for high impact peer-reviewed publications.

Qualifications

+ Doctor of Veterinary Medicine (DVM or equivalent) plus post graduate training in veterinary pathology.

+ Board Certification in Veterinary Anatomic Pathology (ACVP or equivalent) strongly preferred.

+ Candidates with a Ph.D. in pathology or related discipline are strongly preferred.

+ Experience in the Pharmaceutical Industry of 5-7 years.

+ Familiarity with related fields: pharmacology, toxicology and drug development.

+ Seasoned experience in biological research and the ability to work effectively in multidisciplinary teams.

+ Excellent oral and written skills with a proven record of scientific contributions to the scientific community.

+ Proven ability to innovate with a history of successful new or improved scientific applications.

+ Interact well with diverse groups and maintain strong working relationships with internal and external collaborators.

+ Ability to understand others’ points of view and articulate respectfully ones’ own perspective.

+ Ability to negotiate and reconcile interdisciplinary differences, optimizing overall business goals.

+ 5-10 years of experience as a veterinary pathologist in the pharmaceutical business is preferred.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ?

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+ The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.?

+ We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.?

+ This job is eligible to participate in our short-term incentive programs. ?

+ This job is eligible to participate in our long-term incentive programs?

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Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company’s sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. ?

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AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status. US & Puerto Rico only – to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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Job Posting: JC263271971

Posted On: Jul 27, 2024

Updated On: Jul 30, 2024

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