at Adecco US, Inc. in Rockford, Illinois, United States
Job Description
SCIENTIST III – ORGANIC CHEMISTRY / FATTY ACID SYNTHESIS & PROCESS DEVELOPMENT
Location: Rockford, IL
Compensation: $ 50.00/hour
Function: R&D / Organic Chemistry / Process Development
Project: Fatty Acid Synthesis
Number of Openings: 2
Direct Reports: 0
Shift: Day
Relocation: Not approved
Employment Type: Contract / Project-Based
POSITION SUMMARY
The Scientist III will play a critical role in the Fatty Acid Synthesis and Process Development project , developing, optimizing, scaling, and documenting synthetic and purification processes for priority lipid and fatty-acid-related raw materials used to support cell-culture media production.
The Scientist III will apply advanced expertise in organic synthesis, bio-organic chemistry, lipid chemistry, purification, process development, and analytical characterization to establish robust and reproducible processes that meet internal raw-material specifications and are suitable for scale-up and transfer to manufacturing operations.
The ideal candidate will hold a Ph.D. in Organic Chemistry, Bio-Organic Chemistry, or a closely related discipline and have strong hands-on experience with organic synthesis. Experience in bioanalytical characterization and analytical interpretation is highly desirable.
KEY RESPONSIBILITIES
+ Design, plan, and independently execute laboratory experiments for the synthesis and process development of fatty acids, glycerides, phospholipids, and related lipid molecules.
+ Develop and optimize synthetic routes for priority materials, with emphasis on yield, purity, reproducibility, scalability, safety, and raw-material availability.
+ Perform multi-step organic synthesis and reaction optimization to address challenging synthetic targets and process-development needs.
+ Develop and optimize purification strategies using normal-phase and reverse-phase chromatography, preparative HPLC, flash chromatography, crystallization, extraction, precipitation, and other appropriate techniques.
+ Characterize starting materials, intermediates, impurities, and final products using HPLC, LC-MS/MS or MS, NMR, FT-IR, UV/VIS, ELSD/CAD , and other applicable analytical techniques.
+ Interpret analytical data to monitor reactions, confirm identity, assess purity, investigate impurities, and troubleshoot process issues.
+ Investigate impurity profiles and troubleshoot synthesis, purification, stability, and recovery issues that could prevent materials from meeting internal specifications.
+ Conduct feasibility studies using lower-purity or alternate-source starting materials and establish process conditions necessary to achieve target product quality.
+ Support scale-up from laboratory development to gram and hundreds-of-gram quantities.
+ Develop processes suitable for transfer from R&D to Rockford manufacturing operations.
+ Partner with Analytical Development to establish or refine analytical methods for purity, identity, and process-development decision-making.
+ Prepare materials for internal evaluation, packaging/formulation activities, process validation, and manufacturing transfer as required.
+ Prepare experimental protocols, development reports, batch/process instructions, technical summaries, and documentation supporting testing, validation, and production.
+ Maintain complete and accurate laboratory records, including experimental conditions, calculations, raw data, observations, deviations, results, and conclusions.
+ Work cross-functionally with R&D, Analytical Development, Operations, Quality, Procurement/Sourcing, and Project Management teams.
+ Communicate technical results, project status, technical risks, recommendations, and mitigation strategies to project stakeholders.
+ Follow departmental quality systems, chemical hygiene requirements, EHS procedures, and safe laboratory practices.
REQUIRED QUALIFICATIONS
+ Ph.D. in Organic Chemistry, Bio-Organic Chemistry, Medicinal Chemistry, Chemical Sciences, or a closely related scientific discipline.
+ Strong hands-on experience with organic synthesis , including multi-step synthesis and reaction optimization.
+ Demonstrated ability to independently plan and execute synthetic chemistry experiments.
+ Experience developing and optimizing purification processes for complex organic molecules.
+ Hands-on experience with preparative purification techniques, including chromatography and related methods.
+ Strong ability to interpret HPLC, LC-MS/MS or MS, NMR, and FT-IR data.
+ Experience using analytical data for reaction monitoring, identity confirmation, purity assessment, and impurity troubleshooting.
+ Ability to independently troubleshoot synthetic and purification challenges and design experiments to resolve technical problems.
+ Experience documenting laboratory work in a manner appropriate for process development, technical transfer, and quality-controlled environments.
+ Ability to work independently while collaborating effectively within a cross-functional R&D environment.
+ Strong written, verbal, technical, and data-presentation skills.
PREFERRED QUALIFICATIONS
+ Industrial experience in lipid chemistry, fatty-acid chemistry, bio-organic chemistry, glycerides, phospholipids, surfactants, or related molecules .
+ Experience synthesizing or purifying phosphatidylcholines, diacylglycerols, or structurally related lipid molecules.
+ Bioanalytical experience involving characterization of organic or lipid-based compounds.
+ Hands-on experience with Biotage Isolera, Biotage Selekt , or comparable flash/preparative chromatography systems.
+ Experience with CAD or ELSD detection for lipid and non-chromophoric compounds.
+ Experience scaling synthetic chemistry processes from small-scale feasibility studies to gram or hundreds-of-gram quantities.
+ Experience with reagent/raw-material product development, process validation, change control, or transfer of R&D processes to manufacturing.
+ Working knowledge of raw-material specifications, supplier qualification, and technical evaluation of alternate-source materials.
+ Experience working in regulated, quality-controlled, or GMP-related laboratory environments.
EDUCATION
Required:
Ph.D. in Organic Chemistry, Bio-Organic Chemistry, Medicinal Chemistry, Chemical Sciences, or a closely related scientific discipline.
Additional consideration:
Candidates with an M.S. or Bachelor’s degree may be considered when accompanied by substantial, directly relevant industrial synthetic chemistry experience.
Core educational requirement:
Ph.D.-level expertise in Organic Chemistry, Bio-Organic Chemistry, or a related discipline , with demonstrated hands-on organic synthesis experience.
CORE TECHNICAL COMPETENCIES
+ Organic Synthesis
+ Multi-Step Synthesis
+ Reaction Optimization
+ Bio-Organic Chemistry
+ Lipid & Fatty-Acid Chemistry
+ Process Development
+ Scale-Up Chemistry
+ Purification & Chromatography
+ Preparative HPLC
+ Flash Chromatography
+ HPLC
+ LC-MS/MS / Mass Spectrometry
+ NMR
+ FT-IR
+ ELSD / CAD
+ Impurity Investigation
+ Analytical Data Interpretation
+ Technical Documentation
+ Process Transfer
+ Cross-Functional R&D Collaboration
SUCCESS MEASURES
+ Project development milestones are completed according to the established project plan.
+ Target materials consistently meet required identity, purity, and quality specifications.
+ Developed processes demonstrate acceptable yield, reproducibility, scalability, and operational practicality.
+ Technical risks, deviations, and process challenges are identified early and investigated using sound scientific methodology.
+ Clear mitigation strategies
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